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KMID : 0361620110460040273
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Journal of the Korean Orthopaedic Association
2011 Volume.46 No. 4 p.273 ~ p.281
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The Effect of Cefazolin on Mechanical Properties and Antibacterial Reactions of Calcium Phosphate Cement
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Kwon Ki-Dae
Chang Jae-Suk
Lee Soo-Ho
Lee Dong-Ho
Lee Kang-Sik
Hwang Ji-Hyo
Lee Hee-Sang
Byun Seong-Eun
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Abstract
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Purpose: The purpose of this study is to evaluate the change of mechanical properties and the effect of antibacterial reactions in calcium phosphate cement (CPC) mixed with cefazolin.
Materials and Methods : We made CPC and a sodium alginate solution and we mixed in variable dosages of cefazolin and then we made a standard sized cement mold. With that we performed compression stress tests, drug releasing tests and antibacterial tests.
Results: We found the typical appearance of hydroxyapatite (HA) in the cement mixed with cefazolin. The compressive strength of the cement mixed with cefazolin was higher than that of the cement not mixed with cefazolin and the higher strength cement had a smaller pore size and less porosity. The sodium alginate solution showed the maximum compressive strength at 2 & 4 wt%, but this was decreased at 6 wt%. Cefazolin was released in proportion to the concentration for the first 8 days on the drug releasing test and then a similar amount was released until the tenth day. An antibacterial effect was detected at all dosages of cefazolin on the anti bacterial test.
Conclusion: The compressive strength of the cement mixed with cefazolin was higher than that of the cement not mixed with cefazolin. The drug was released from the cement in a proper fashion and the antibacterial effect was preserved.
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KEYWORD
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calcium phosphate cement, cefazolin, compressive strength, antibacterial
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